Peptoclostridium (Clostridium) difficile (commonly nicknamed “Cdiff”) is a spore-forming bacterium that causes serious healthcare-associated infections. In the United States alone, it is estimated that Cdiff infections were responsible for more than 29,000 deaths in 20111. Antibiotic resistance and recurrent infections are common problems in treating Cdiff infections.
The BioCyc collection currently contains twelve Clostridium/Peptoclostridium difficile databases; all of them can be easily accessed from a new home page, http://cdifficile.biocyc.org/. We chose the database for a strain commonly used in the laboratory, Peptoclostridium difficile 630, for a pilot project to update the genome annotation and to add literature curation.